Association of spinal degenerative disc disease with thyroid autoimmunity

Autoimmune thyroiditis (ATD) has been linked to various forms of arthritis. The relationship with spinal degenerative disc disease (DDD) is not known. We studied the association between ATD and spinal DDD. We performed a cross-sectional analysis of patients who had data on both anti-thyroid peroxida...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2016-03, Vol.34 (2), p.296-302
Main Authors: Shrestha, Asha, Cohen, Hillel W, Tagoe, Clement E
Format: Article
Language:English
Subjects:
Adult
Aged
Autoantigens - immunology
Body Mass Index
Cross-Sectional Studies
Female
Humans
Intervertebral Disc Degeneration - etiology
Iodide Peroxidase - immunology
Iron-Binding Proteins - immunology
Male
Middle Aged
Thyroiditis, Autoimmune - complications
Thyrotropin - blood
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Summary:Autoimmune thyroiditis (ATD) has been linked to various forms of arthritis. The relationship with spinal degenerative disc disease (DDD) is not known. We studied the association between ATD and spinal DDD. We performed a cross-sectional analysis of patients who had data on both anti-thyroid peroxidase antibodies (TPOAb) and anti-thyroglobulin antibodies (TgAb) from January 1997 to January 2014 in Clinical Looking Glass (CLG), a data analysis software platform. Spinal DDD was confirmed by radiological diagnosis. Of the 7698 patients for whom the TPOAb and TgAb values were available, 4383 patients with complete data for the following covariates; age, gender, race, ethnicity, smoking, diabetes, body mass index and thyroid stimulating hormone (TSH) levels, were included. Thirty-three percent had ATD, while 67% did not. The unadjusted odds ratio (OR) of having spinal DDD with ATD was 1.5 (95% confidence interval (CI)1.3, 1.7), p
ISSN:0392-856X