Effect of antepartum meconium staining on perinatal and neonatal outcomes among pregnancies with gastroschisis

Objective: To investigate the association between meconium staining and perinatal and neonatal outcomes in pregnancies with gastroschisis. Methods: Retrospective analysis of infants with prenatally diagnosed gastroschisis born in two academic medical centers between 2008 and 2013. Neonatal outcomes...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2016-01, Vol.29 (15), p.2499-2503
Main Authors: Girsen, Anna I., Wallenstein, Matthew B., Davis, Alexis S., Hintz, Susan R., Desai, Arti K., Mansour, Trina, Merritt, T. Allen, Druzin, Maurice L., Oshiro, Bryan T., Blumenfeld, Yair J.
Format: Article
Language:English
Subjects:
Adult
Amniotic Fluid - chemistry
Cohort Studies
Delivery, Obstetric
Female
Gastroschisis
Gastroschisis - complications
Humans
Infant, Newborn
Infant, Newborn, Diseases - epidemiology
Infant, Newborn, Diseases - etiology
Infant, Premature
Length of Stay
Meconium
neonatal
outcome
Pregnancy
Pregnancy Complications
Pregnancy Outcome
prematurity
Retrospective Studies
Staining and Labeling
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Summary:Objective: To investigate the association between meconium staining and perinatal and neonatal outcomes in pregnancies with gastroschisis. Methods: Retrospective analysis of infants with prenatally diagnosed gastroschisis born in two academic medical centers between 2008 and 2013. Neonatal outcomes of deliveries with and without meconium staining were compared. Primary outcome was defined as any of the following: neonatal sepsis, prolonged mechanical ventilation, bowel atresia or death. Secondary outcomes were preterm delivery, preterm-premature rupture of membranes (PPROM) and prolonged hospital length of stay. Results: One hundred and eight infants with gastroschisis were included of which 56 (52%) had meconium staining at delivery. Infants with meconium staining had a lower gestational age at delivery (36.3 (±1.4) versus 37.0 (±1.2) weeks, p = 0.007), and a higher rate of PPROM (25% versus 8%, p = 0.03) than infants without meconium. Meconium staining was not significantly associated with the primary composite outcome or with any of its components. After adjustments, meconium staining remained significantly associated with preterm delivery at 
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2015.1090971