Stability, Prognostic Factors and Survival of Spinal Bone Metastases in Malignant Melanoma Patients after Palliative Radiotherapy

Purpose This retrospective analysis aimed to evaluate the stability of spinal metastases in malignant melanoma patients following radiotherapy (RT), and to assess prognostic factors for survival. Methods Forty-one patients with malignant melanoma and osteolytic spinal bone metastases were irradiated...

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Bibliographic Details
Published in:Tumori 2016-03, Vol.102 (2), p.156-161
Main Authors: Bostel, Tilman, Förster, Robert, Schlampp, Ingmar, Wolf, Robert, Serras, Andre Franke, Mayer, Arnulf, Bruckner, Thomas, Welzel, Thomas, Schmidberger, Heinz, Debus, Jürgen, Rief, Harald
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Bone Density Conservation Agents - administration & dosage
Braces
Diphosphonates - administration & dosage
Female
Humans
Joint Instability - etiology
Kaplan-Meier Estimate
Karnofsky Performance Status
Lumbar Vertebrae - pathology
Male
Melanoma - complications
Melanoma - mortality
Melanoma - radiotherapy
Melanoma - secondary
Middle Aged
Palliative Care - methods
Predictive Value of Tests
Prognosis
Radiotherapy Dosage
Retrospective Studies
Risk Assessment
Risk Factors
Skin Neoplasms - pathology
Spinal Neoplasms - complications
Spinal Neoplasms - mortality
Spinal Neoplasms - radiotherapy
Spinal Neoplasms - secondary
Thoracic Vertebrae - pathology
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Summary:Purpose This retrospective analysis aimed to evaluate the stability of spinal metastases in malignant melanoma patients following radiotherapy (RT), and to assess prognostic factors for survival. Methods Forty-one patients with malignant melanoma and osteolytic spinal bone metastases were irradiated at the university clinics of Heidelberg and Mainz between July 2003 and October 2013. Three and six months after palliative RT, only 20 and 15 patients, respectively, were still alive and were therefore assessed for spinal stability using the Taneichi score based on CT imaging. Additionally, overall survival (OS) and bone survival (BS) rates as well as prognostic factors for BS were evaluated for all study patients. Results Before RT, 19 patients (46.3%) were rated unstable. In the surviving patients, none of the unstable metastases were classified as stable 6 months after RT. Five-year OS was 23.3% and median BS was 4 months (range 0.5-29.8). Accordingly, only 36.6% of the patients were still alive 6 months after RT. Karnofsky performance score (KPS)
ISSN:0300-8916
2038-2529
DOI:10.5301/tj.5000382