Gene duplication and complex circadian clocks in mammals

The circadian clock arose early in the evolution of life to enable organisms to adapt to the cycle of day and night. Recently, the extent and importance of circadian regulation of behaviour and physiology has come to be more fully realized. Core molecular cogs of circadian oscillators appear to have...

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Bibliographic Details
Published in:Trends in genetics 2005, Vol.21 (1), p.46-53
Main Authors: Looby, Paul, Loudon, Andrew S.I.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological Clocks - genetics
Diptera - genetics
Drosophila Proteins
Fundamental and applied biological sciences. Psychology
Gene Duplication
Genetics of eukaryotes. Biological and molecular evolution
Male
Mammalia
Mammals - genetics
Models, Genetic
Molecular and cellular biology
Nuclear Proteins - genetics
Period Circadian Proteins
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Summary:The circadian clock arose early in the evolution of life to enable organisms to adapt to the cycle of day and night. Recently, the extent and importance of circadian regulation of behaviour and physiology has come to be more fully realized. Core molecular cogs of circadian oscillators appear to have been largely conserved between such diverse organisms as Drosophila melanogaster and mammals. However, gene duplication events have produced multiple copies of many clock genes in mammals. Recent studies suggest that genome duplication has lead to increased circadian complexity and local tissue regulation. This has important implications for temporal regulation of behaviour via multiple clocks in the central nervous system, and also extends to the local physiology of major body organs and tissues.
ISSN:0168-9525
DOI:10.1016/j.tig.2004.11.012