Opposing pharmacological actions of cepharanthin on lipopolysaccharide-induced histidine decarboxylase activity in mice spleens

A biscoclaurin alkaloid preparation, cepharanthin (Ceph), is reported to have opposing pharmacological effects, enhancement or depression, on several cells and tissues, although detailed mechanisms remain unclear. Previously, we reported that Ceph enhanced lipopolysaccharide (LPS)-induced histidine...

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Bibliographic Details
Published in:Life sciences (1973) 2001-02, Vol.68 (12), p.1395-1403
Main Authors: Sogawa, Norio, Sogawa, Chiharu Aoki, Abuku, Eiko Iwata, Inoue, Tetsuyoshi, Oda, Nariaki, Kishi, Kanji, Furuta, Hiroaki
Format: Article
Language:English
Subjects:
Alkaloids - pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Benzylisoquinolines
Cell Degranulation - drug effects
Cell Degranulation - genetics
Cepharanthin
cepharanthine
Dose-Response Relationship, Drug
Drug Interactions
Escherichia coli - immunology
Histidine decarboxylase
Histidine Decarboxylase - biosynthesis
Lipopolysaccharide
Lipopolysaccharides - pharmacology
Male
Mast cell-deficient
Mast Cells - drug effects
Mast Cells - pathology
Mast Cells - physiology
Mice
Mice, Inbred ICR - genetics
Mice, Knockout
Skin - drug effects
Skin - pathology
Spleen - drug effects
Spleen - enzymology
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Summary:A biscoclaurin alkaloid preparation, cepharanthin (Ceph), is reported to have opposing pharmacological effects, enhancement or depression, on several cells and tissues, although detailed mechanisms remain unclear. Previously, we reported that Ceph enhanced lipopolysaccharide (LPS)-induced histidine decarboxylase (HDC) activity in mice spleens by consecutive pre-administration. In this study, we examined the pharmacological effects on HDC activity of a single Ceph pre-administration to test the influence of the administration method. Consequently, HDC activities were decreased by a single administration 15 minutes before LPS challenge in ddY and ICR mice spleens. Moreover, to further examine this suppressing effect, we employed genetically mast cell-deficient WBB6F1 W/W v (W/W v) mice to avoid the influence of mast cells. In W/W v mice, HDC activity was enhanced, but not in the congenic WBB6F1 +/+ mice. These findings suggest that mast cells influence the depressant effect on HDC activity by a Ceph single administration in mast cell sufficient mice.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(00)01041-9