Influence of Val108/158Met COMT Gene Polymorphism on the Efficacy of Modified Electroconvulsive Therapy in Patients with Treatment Resistant Depression

Depression is a common emotional disorder associated with increased risk of suicide and rate of disability. In this double-blinded control study, we tested the efficacy of modified electroconvulsive therapy (MECT) in patients with treatment resistant depression (TRD) using the Hamilton Depression Ra...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2015-04, Vol.71 (3), p.1387-1393
Main Authors: Lin, Zhaoyu, He, Hongbo, Zhang, Chunping, Wang, Zhijie, Jiang, Miaoling, Li, Qirong, Lan, Xiaochang, Zhang, Minling, Huang, Xiong
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Case-Control Studies
Catechol O-Methyltransferase - genetics
Cell Biology
Depressive Disorder, Treatment-Resistant - enzymology
Depressive Disorder, Treatment-Resistant - genetics
Depressive Disorder, Treatment-Resistant - therapy
Electroconvulsive Therapy
Female
Genotype
Humans
Life Sciences
Male
Middle Aged
Original Paper
Pharmacology/Toxicology
Polymorphism, Single Nucleotide
Suicide
Treatment Outcome
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Summary:Depression is a common emotional disorder associated with increased risk of suicide and rate of disability. In this double-blinded control study, we tested the efficacy of modified electroconvulsive therapy (MECT) in patients with treatment resistant depression (TRD) using the Hamilton Depression Rating Scale for Depression (HAMD). The total scores of HAMD were found to be significantly decreased after the treatment. The genotyping of catechol-O-methyltransferase (COMT) was carried out with polymerase chain reaction-based testing. Our results demonstrated that frequency of mutant COMT alleles in TRD patients was significantly higher than that of the controls indicating a correlation of the enzyme genotype to the occurrence of TRD. Moreover, the patients homozygous for wild-type COMT gene (G/G) were evidenced to be more sensitive to MECT treatment than those with an heterozygous mutant genotype (A/G).
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-014-0361-2