IL4‐R1 (5q31–q33) and FcεRI‐βca (11q13) markers and atopy: a case/control study in a Spanish population

• Published in: Allergy (Copenhagen) 2001-02, Vol.56 (2), p.159-163
• Main Authors: Torres‐Galván, M., Quiralte, J., Pestano, J. J., Ortega, N., Blanco, C., Castillo, R., Carrillo, T., Pérez‐Aciego, P., Sánchez‐García, F.
• Format: Article
• Language: English
• Subjects: AFc receptors; Allergic diseases; association; atopy; Biological and medical sciences; chromosome 11; Dermatophagoides pteronyssinus; FcεRI‐β; IL‐4; Immunopathology; Medical sciences; microsatellite; Skin allergic diseases. Stinging insect allergies
• ISSN: 0105-4538; 1398-9995
• DOI: 10.1034/j.1398-9995.2001.056002159.x

Background: Rhinoconjunctivitis and bronchial asthma are atopic diseases with a high prevalence in the Canary Islands (Spain). Given that the most prevalent allergen is the house‐dust mite Dermatophagoides pteronyssinus, early detection of genetically susceptible subjects would allow the application of preventive measures. The objective was to investigate the possible association of IL4‐R1 (chromosome 5q31–q33) and FcεRI‐βca (chromosome 11q13) markers with the atopic disease in our population. Methods: We performed a case/control study in which patients were recruited on the basis of diagnosis of rhinoconjunctivitis and/or bronchial asthma, and positive skin prick test to D. pteronyssinus. Analysis of IL4‐R1 and FcεRI‐βca microsatellites was carried out by PCR and electrophoresis in acrylamide gels. Results: We have not found evidence of association between IL4‐R1 and FcεRI‐βca markers and atopic disease in our population. In addition, these markers have shown a high percentage of homozygosis. Conclusions: IL4‐R1 and FcεRI‐βca markers have not proved to be useful genetic markers for linkage or association studies in our population.