Salvage total laryngectomy after external-beam radiotherapy: A 20-year experience

Background The purpose of this study was to present our evaluation of the clinical and functional outcomes after salvage total laryngectomy (STL). Methods We conducted a retrospective review of 218 patients who underwent STL between 1994 and 2014. Results Seventy percent of patients originally had T...

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Bibliographic Details
Published in:Head & neck 2016-04, Vol.38 (S1), p.E1962-E1968
Main Authors: Sandulache, Vlad C., Vandelaar, Laura J., Skinner, Heath D., Cata, Juan, Hutcheson, katherine, Fuller, Clifton David, Phan, Jack, Siddiqui, Zuhair, Lai, Stephen Y., Weber, Randal S., Zafereo, Mark E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - radiotherapy
Carcinoma, Squamous Cell - surgery
complications
disease-free interval
Disease-Free Survival
Female
fistula
Follow-Up Studies
free flap
Humans
Laryngeal Neoplasms - radiotherapy
Laryngeal Neoplasms - surgery
Laryngectomy
Male
Middle Aged
Neoplasm Recurrence, Local
radiotherapy
recurrence
Retrospective Studies
salvage
Salvage Therapy
squamous cell carcinoma
Survival Rate
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Summary:Background The purpose of this study was to present our evaluation of the clinical and functional outcomes after salvage total laryngectomy (STL). Methods We conducted a retrospective review of 218 patients who underwent STL between 1994 and 2014. Results Seventy percent of patients originally had T1 or T2, N0 tumors and 73% had definitive external‐beam radiotherapy (EBRT) alone. A majority utilized tracheoesophageal prosthesis (77%) and were gastrostomy free (80%) at last follow‐up. The 5‐year disease control and overall survival (OS) rates were 65% and 57%, respectively. Patients with a disease‐free interval after initial treatment 5‐year disease‐free interval and 60% for
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.24355