Adjuvant radiation therapy in resected high-grade localized skeletal osteosarcomas treated with neoadjuvant chemotherapy: Long-term outcomes

Abstract Purpose To assess long-term outcomes and toxicity of adjuvant radiotherapy in the post-surgical management of patients with resected high-grade skeletal osteosarcomas. Methods and materials Seventy-two patients with primary resected osteosarcomas underwent adjuvant radiotherapy after neoadj...

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Bibliographic Details
Published in:Radiotherapy and oncology 2016-04, Vol.119 (1), p.30-34
Main Authors: Sole, Claudio V, Calvo, Felipe A, Alvarez, Eduardo, Cambeiro, Mauricio, Cuervo, Miguel, San Julian, Mikel, Sole, Sebastian, Martinez-Monge, Rafael, Sierrasesumaga, Luis
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bone Neoplasms - drug therapy
Bone Neoplasms - radiotherapy
Chemotherapy, Adjuvant
Child
Child, Preschool
Disease-Free Survival
Female
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Humans
Local control
Male
Middle Aged
Multivariate Analysis
Neoadjuvant Therapy - methods
Osteosarcoma - drug therapy
Osteosarcoma - radiotherapy
Osteosarcomas
Proportional Hazards Models
Radiotherapy
Radiotherapy, Adjuvant
Survival Rate
Treatment Outcome
Young Adult
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Summary:Abstract Purpose To assess long-term outcomes and toxicity of adjuvant radiotherapy in the post-surgical management of patients with resected high-grade skeletal osteosarcomas. Methods and materials Seventy-two patients with primary resected osteosarcomas underwent adjuvant radiotherapy after neoadjuvant chemotherapy from December 1984 to December 2008. Local control (LC), overall survival (OS) and disease-free survival (DFS) were estimated using Kaplan–Meier methods. For survival outcomes potential associations were assessed in univariate and multivariate analyses using the Cox proportional hazards model. Results After a median follow-up of 174 months (range, 33–363 months), 10-year LC, DFS, and OS rates were 82%, 58%, and 73%, respectively. In the multivariate analysis only R1 margin status ( p = 0.02) remained significantly associated with LC. Patients with tumor necrosis
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2016.02.029