Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test

Background and Objectives Preoperatively evaluating reserved liver function is critical in preventing posthepatectomy liver failure (PHLF) in patients undergoing liver resection. The commonly used indocyanine green (ICG) clearance test has several drawbacks. Patients would benefit from a more reliab...

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Bibliographic Details
Published in:Journal of surgical oncology 2016-04, Vol.113 (5), p.565-569
Main Authors: Tomimaru, Yoshito, Eguchi, Hidetoshi, Gotoh, Kunihito, Kawamoto, Koichi, Wada, Hiroshi, Asaoka, Tadafumi, Noda, Takehiro, Yamada, Daisaku, Ogawa, Hisataka, Umeshita, Koji, Nagano, Hiroaki, Doki, Yuichiro, Mori, Masaki
Format: Article
Language:English
Subjects:
Aged
Cancer surgery
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - surgery
Coloring Agents - pharmacokinetics
Female
hepatectomy
Hepatectomy - adverse effects
hepatocellular carcinoma
Humans
Incidence
indocyanine green
Indocyanine Green - pharmacokinetics
Liver cancer
Liver Failure - epidemiology
Liver Failure - metabolism
Liver Neoplasms - metabolism
Liver Neoplasms - surgery
Logistic Models
Male
Middle Aged
platelet
Platelet Count
posthepatectomy liver failure
Postoperative Complications - epidemiology
Postoperative Complications - metabolism
Predictive Value of Tests
Retrospective Studies
Risk Factors
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Summary:Background and Objectives Preoperatively evaluating reserved liver function is critical in preventing posthepatectomy liver failure (PHLF) in patients undergoing liver resection. The commonly used indocyanine green (ICG) clearance test has several drawbacks. Patients would benefit from a more reliable and straightforward means of assessing the risk of PHLF. Methods This study included 277 patients with hepatocellular carcinoma (HCC) undergoing liver resection. The predictive value of known risk factors for PHLF was compared to that of ICG. Results PHLF was identified in 25 out of 277 patients (9.0%). Multivariate logistic regression analysis for identifying predictors for the PHLF development revealed platelet count and resected liver volume as significant independent predictors. In a subgroup analysis based on resected liver volume, platelet count was significantly correlated with PHLF in both larger volume (≥100 g) and smaller volume resection groups (
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.24166