The role of carbon monoxide and nitric oxide in hyperosmolality-induced atrial natriuretic peptide release by hypothalamus in vitro

We evaluated the participation of the nitrergic and carbon monoxide (CO) systems in the atrial natriuretic peptide (ANP) release induced by osmotic stimulation of the rat anterior and medial basal hypothalamus (BH) fragments in vitro. The increase in the medium osmolality (NaCl, 340 mOsm/kg H 2O) in...

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Bibliographic Details
Published in:Brain research 2004-07, Vol.1016 (1), p.33-39
Main Authors: Gomes, Dayane Aparecida, Reis, Wagner Luiz, Ventura, Renato Rizo, Giusti-Paiva, Alexandre, Elias, Lucila Leico Kagohara, Cunha, Fernando Queiroz, Antunes-Rodrigues, Jose
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
ANP
Atrial Natriuretic Factor - metabolism
Biochemistry and metabolism
Biological and medical sciences
Carbon monoxide
Carbon Monoxide - physiology
Central nervous system
Citrulline - metabolism
Dose-Response Relationship, Drug
Drug Interactions
Enzyme Inhibitors - pharmacology
Fundamental and applied biological sciences. Psychology
Hemoglobins - pharmacology
Hyperosmolality
Hypothalamus
Hypothalamus - drug effects
Hypothalamus - metabolism
In Vitro Techniques
Male
NG-Nitroarginine Methyl Ester - pharmacology
Nitrates - metabolism
Nitric oxide
Nitric Oxide - physiology
Nitric Oxide Donors - pharmacology
omega-N-Methylarginine - pharmacology
Osmolar Concentration
Potassium Chloride - pharmacology
Rats
Vertebrates: nervous system and sense organs
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Summary:We evaluated the participation of the nitrergic and carbon monoxide (CO) systems in the atrial natriuretic peptide (ANP) release induced by osmotic stimulation of the rat anterior and medial basal hypothalamus (BH) fragments in vitro. The increase in the medium osmolality (NaCl, 340 mOsm/kg H 2O) induced an elevated ANP release, which was associated with a decrease in nitric oxide synthase (NOS) activity ( p
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2004.04.047