Outcomes of initial surgery in patients with clinical N2 non-small cell lung cancer who met 4 specific criteria

Purpose The role of surgery for patients with non-small cell lung cancer (NSCLC) with clinical mediastinal lymph node metastasis (N2) remains controversial. We specified 4 criteria for performing initial surgery in these patients (single-station N2, non-bulky N2, N2 with regional mode of spread, and...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2016-06, Vol.46 (6), p.699-704
Main Authors: Maniwa, Tomohiro, Takahashi, Shoji, Isaka, Mitsuhiro, Endo, Masahiro, Ohde, Yasuhisa
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Chemotherapy, Adjuvant
Female
Follow-Up Studies
Humans
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Lymph Node Excision
Lymphatic Metastasis
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Pneumonectomy
Positron-Emission Tomography
Surgery
Surgical Oncology
Time Factors
Treatment Outcome
Young Adult
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Summary:Purpose The role of surgery for patients with non-small cell lung cancer (NSCLC) with clinical mediastinal lymph node metastasis (N2) remains controversial. We specified 4 criteria for performing initial surgery in these patients (single-station N2, non-bulky N2, N2 with regional mode of spread, and N2 without N1) and examined the outcomes to validate the treatment options. Methods Between September 2002 and December 2010, of 1290 patients who underwent complete resection for NSCLC, 808 patients underwent initial standard resection, including 779 patients with cN0–1 and 29 with cN2. We compared the outcomes, and evaluated patients with cN2–pN2. Results The median follow-up was 45.5 months (3–119 months). Seventy (9.0 %) and 24 (82.8 %) patients had p-N2 in the cN0–1 and cN2 groups, respectively ( p  
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-015-1268-2