Striatal structure and function predict individual biases in learning to avoid pain

• Published in: Proceedings of the National Academy of Sciences - PNAS 2016-04, Vol.113 (17), p.4812-4817
• Main Authors: Eldar, Eran, Hauser, Tobias U., Dayan, Peter, Dolan, Raymond J.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Avoidance Learning - physiology; Behavior; Bias; Biological Sciences; Brain Mapping; Choice Behavior - physiology; Corpus Striatum - physiology; Decision Making - physiology; Electroshock; Female; Gambling; Games, Experimental; Humans; Individuality; Learning; Learning - physiology; Magnetic Resonance Imaging; Male; Mental disorders; Oxygen - blood; Pain; Pain - prevention & control; Prevention; Social Sciences; Young Adult
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.1519829113

Pain is an elemental inducer of avoidance. Here, we demonstrate that people differ in how they learn to avoid pain, with some individuals refraining from actions that resulted in painful outcomes, whereas others favor actions that helped prevent pain. These individual biases were best explained by differences in learning from outcome prediction errors and were associated with distinct forms of striatal responses to painful outcomes. Specifically, striatal responses to pain were modulated in a manner consistent with an aversive prediction error in individuals who learned predominantly from pain, whereas in individuals who learned predominantly from success in preventing pain, modulation was consistent with an appetitive prediction error. In contrast, striatal responses to success in preventing pain were consistent with an appetitive prediction error in both groups. Furthermore, variation in striatal structure, encompassing the region where pain prediction errors were expressed, predicted participants’ predominant mode of learning, suggesting the observed learning biases may reflect stable individual traits. These results reveal functional and structural neural components underlying individual differences in avoidance learning, which may be important contributors to psychiatric disorders involving pathological harm avoidance behavior.