Testicular germ cell tumours

Summary Testicular germ cell tumours are at the crossroads of developmental and neoplastic processes. Their cause has not been fully elucidated but differences in incidences suggest that a combination of genetic and environment factors are involved, with environmental factors predominating early in...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 2016-04, Vol.387 (10029), p.1762-1774
Main Authors: Rajpert-De Meyts, Ewa, DMSc, McGlynn, Katherine A, PhD, Okamoto, Keisei, Dr, Jewett, Michael A S, Prof, Bokemeyer, Carsten, Prof
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer therapies
Chemotherapy
Chemotherapy, Adjuvant
Environmental factors
Epidemiology
Genetics
Genome-Wide Association Study
Health risk assessment
Humans
Internal Medicine
Male
Medical prognosis
Mutation
Neoplasms, Germ Cell and Embryonal - epidemiology
Neoplasms, Germ Cell and Embryonal - genetics
Neoplasms, Germ Cell and Embryonal - therapy
Orchiectomy
Pathogenesis
Proto-Oncogene Proteins c-kit - genetics
Quality of life
Radiotherapy, Adjuvant
ras Proteins - genetics
Risk factors
Testicular cancer
Testicular Neoplasms - epidemiology
Testicular Neoplasms - genetics
Testicular Neoplasms - therapy
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Testicular germ cell tumours are at the crossroads of developmental and neoplastic processes. Their cause has not been fully elucidated but differences in incidences suggest that a combination of genetic and environment factors are involved, with environmental factors predominating early in life. Substantial progress has been made in understanding genetic susceptibility in the past 5 years on the basis of the results of large genome-wide association studies. Testicular germ cell tumours are highly sensitive to radiotherapy and chemotherapy and hence have among the best outcomes of all tumours. Because the tumours occur mainly in young men, preservation of reproductive function, quality of life after treatment, and late effects are crucial concerns. In this Seminar, we provide an overview of advances in the understanding of the epidemiology, genetics, and biology of testicular germ cell tumours. We also summarise the consensus on how to treat testicular germ cell tumours and focus on a few controversies and improvements in the understanding of late effects of treatment and quality of life for survivors.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(15)00991-5