Fucoidan ameliorates steatohepatitis and insulin resistance by suppressing oxidative stress and inflammatory cytokines in experimental non-alcoholic fatty liver disease

Highlights • Fucoidan alleviated high-fat diet-induced hepatic and metabolic disorders in rats. • Results suggest hypolipidemic, insulin sensitizing, antioxidant and anti-inflammatory/anti-fibrotic mechanisms of fucoidan. • Fucoidan modulated the expressions of tumor necrosis factor-α, interleukins-...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2015-11, Vol.40 (3), p.907-914
Main Authors: Heeba, Gehan H, Morsy, Mohamed A
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Antioxidants - administration & dosage
Antioxidants - pharmacology
Cytokines - genetics
Diet, High-Fat - adverse effects
Disease Models, Animal
Emergency
Fucoidan
Gene Expression Regulation - drug effects
High-fat diet
Inflammatory cytokines
Insulin Resistance - genetics
Insulin Resistance - immunology
Male
Metformin
Metformin - administration & dosage
Metformin - pharmacology
NAFLD
Non-alcoholic Fatty Liver Disease - chemically induced
Non-alcoholic Fatty Liver Disease - drug therapy
Non-alcoholic Fatty Liver Disease - genetics
Non-alcoholic Fatty Liver Disease - immunology
Oxidative stress
Oxidative Stress - drug effects
Polysaccharides - administration & dosage
Polysaccharides - pharmacology
Rats
Rats, Wistar
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Summary:Highlights • Fucoidan alleviated high-fat diet-induced hepatic and metabolic disorders in rats. • Results suggest hypolipidemic, insulin sensitizing, antioxidant and anti-inflammatory/anti-fibrotic mechanisms of fucoidan. • Fucoidan modulated the expressions of tumor necrosis factor-α, interleukins-1β and matrix metalloproteinase-2.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.10.003