Metformin prevents cerebellar granule neurons against glutamate-induced neurotoxicity

Highlights • Metformin pretreatment protects CGNs against glutamate neuronal toxicity. • Metformin reduces glutamate-induced Caspase 3 activation. • Glutamate-induced JNK and p38 phosphorylation are inhibited by metformin.

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Bibliographic Details
Published in:Brain research bulletin 2016-03, Vol.121, p.241-245
Main Authors: Zhou, Changwei, Sun, Rong, Zhuang, Sujuan, Sun, Chongyi, Jiang, Yongqing, Cui, Yang, Li, Shitou, Xiao, Yanqiu, Du, Yansheng, Gu, Huiying, Liu, Qingpeng
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Apoptosis - drug effects
Caspase 3 - metabolism
Cells, Cultured
Cerebellar granule neurons
Cerebellum - cytology
Cytochromes c - metabolism
Dose-Response Relationship, Drug
Drug Interactions
Excitatory Amino Acid Agonists - toxicity
Excitotoxicity
Glutamate
Glutamic Acid - toxicity
Male
MAP Kinase Kinase 4 - metabolism
MAP Kinase Signaling System - drug effects
MAPK
Metformin
Metformin - pharmacology
Neurology
Neurons - drug effects
Neuroprotection
Neuroprotective Agents - pharmacology
Rats
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Description
Summary:Highlights • Metformin pretreatment protects CGNs against glutamate neuronal toxicity. • Metformin reduces glutamate-induced Caspase 3 activation. • Glutamate-induced JNK and p38 phosphorylation are inhibited by metformin.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2016.02.009