PRDM1 is directly targeted by miR-30a-5p and modulates the Wnt/β-catenin pathway in a Dkk1-dependent manner during glioma growth

Highlights ► PRDM1 is down-regulated in glioma. ► PRDM1 elicits the expression of Dkk1. ► PRDM1 suppresses the activity of Wnt/β-catenin pathway. ► PRDM1 is a direct target for miR-30a-5p.

Saved in:
Bibliographic Details
Published in:Cancer letters 2013-05, Vol.331 (2), p.211-219
Main Authors: Wang, Xuan, Wang, Kun, Han, Lei, Zhang, Anling, Shi, Zhendong, Zhang, Kailiang, Zhang, Hongwei, Yang, Shaohua, Pu, Peiyu, Shen, Changhong, Yu, Chunjiang, Kang, Chunsheng
Format: Article
Language:English
Subjects:
Animals
beta Catenin - metabolism
bioinformatics
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
carcinogenesis
Cell Division
Dkk1
Glioma
Glioma - metabolism
Glioma - pathology
Hematology, Oncology and Palliative Medicine
Humans
Intercellular Signaling Peptides and Proteins - physiology
Mice
Mice, Inbred BALB C
Mice, Nude
MicroRNAs - metabolism
miR-30a-5p
patients
phenotype
Positive Regulatory Domain I-Binding Factor 1
PRDM1
Real-Time Polymerase Chain Reaction
Repressor Proteins - metabolism
Retrospective Studies
Signal Transduction
transcription (genetics)
Wnt Proteins - metabolism
β-Catenin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► PRDM1 is down-regulated in glioma. ► PRDM1 elicits the expression of Dkk1. ► PRDM1 suppresses the activity of Wnt/β-catenin pathway. ► PRDM1 is a direct target for miR-30a-5p.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.01.005