Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses

Abstract Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects. Here, we examined the effects of berberine on dopamine receptors and the ensuing anti-inflammatory responses. Berberine was found to be an antagonist at both dopamine...

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Bibliographic Details
Published in:Journal of neuroimmunology 2015-12, Vol.289, p.43-55
Main Authors: Kawano, Masaaki, Takagi, Rie, Kaneko, Atsushi, Matsushita, Sho
Format: Article
Language:English
Subjects:
Adaptive Immunity - drug effects
Allergy and Immunology
Animals
Antagonist
Autoimmune disease
Benzazepines - pharmacology
Berberine
Berberine - therapeutic use
Bone Marrow - pathology
Colitis - chemically induced
Colitis - drug therapy
Colitis - immunology
Colitis - pathology
Cytokines - metabolism
Dendritic Cells - drug effects
Dendritic Cells - metabolism
Dextran Sulfate - toxicity
Disease Models, Animal
Dopamine Antagonists - therapeutic use
Dopamine receptors
Immunity, Innate - drug effects
Innate immune response
Lipopolysaccharides - pharmacology
Lymph Nodes - metabolism
Lymph Nodes - pathology
Lymphocytes - drug effects
Lymphocytes - metabolism
Macrophages - drug effects
Macrophages - pathology
Mice
Mice, Inbred C57BL
Neurology
Protein Binding - drug effects
Pyridines - pharmacology
Pyrroles - pharmacology
Receptors, Dopamine - metabolism
Receptors, Serotonin - metabolism
T helpers
Time Factors
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Description
Summary:Abstract Berberine is an herbal alkaloid with various biological activities, including anti-inflammatory and antidepressant effects. Here, we examined the effects of berberine on dopamine receptors and the ensuing anti-inflammatory responses. Berberine was found to be an antagonist at both dopamine D1- and D2-like receptors and ameliorates the development of experimentally induced colitis in mice. In lipopolysaccharide-stimulated immune cells, berberine treatment modified cytokine levels, consistent with the effects of the dopamine receptor specific antagonists SCH23390 and L750667. Our findings indicate that dopamine receptor antagonists suppress innate and adaptive immune responses, providing a foundation for their use in combatting inflammatory diseases.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2015.10.001