Effects of 5-Pyrimidinol Derivative SNK-41 on Cytokine Profile of Mice with Lewis Lung Carcinoma

We studied the effects of SNK-411, a new 5-pyrimidinol derivative, on serum cytokine profile of C57Bl/6 mice with Lewis lung carcinoma. The compound was injected intraperitoneally in doses of 25 and 50 mg/kg. A significant (by 3.5 times) increase in serum IL-4 content was detected in mice with tumor...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-02, Vol.160 (4), p.483-485
Main Authors: Kuznetsova, O. S., Tallerova, A. V., Nikitin, S. V., Kovalenko, L. P.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Biomedical and Life Sciences
Biomedicine
Carcinoma
Carcinoma, Lewis Lung - drug therapy
Carcinoma, Lewis Lung - pathology
Cell Biology
Disease Models, Animal
House mouse
Immunotherapy
Interleukin-2 - blood
Interleukin-4 - blood
Interleukin-6 - blood
Interleukins
Internal Medicine
Laboratory Medicine
Lung cancer
Mice
Mice, Inbred C57BL
Pathology
Pyrimidines - pharmacology
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Summary:We studied the effects of SNK-411, a new 5-pyrimidinol derivative, on serum cytokine profile of C57Bl/6 mice with Lewis lung carcinoma. The compound was injected intraperitoneally in doses of 25 and 50 mg/kg. A significant (by 3.5 times) increase in serum IL-4 content was detected in mice with tumors on day 9 of tumor development. In mice receiving SNK-411 in doses of 25 and 50 mg/kg, IL-4 content significantly decreased (by 4.0 and 3.6 times) on days 2–8 of carcinoma development; IL-2 content decreased by 1.4 and 1.2 times and IL-6 content decreased by 2.7 and 1.6 times, respectively, in comparison with control mice with tumors. Injections of SNK-411 in the same doses on days 8–15 of carcinoma development led to a significant decrease in IL-4 levels (by 2.2 and 4.5 times, respectively, in comparison with control mice with tumors) and did not affect serum levels of other cytokines.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3202-z