Morphofunctional Characteristics of the Glutathione Cycle in Peripheral Blood Erythrocytes of Pregnant Women with a History of Cytomegalovirus Infection Exacerbation during Gestation

We studied factors infl uencing peripheral blood erythrocytes of pregnant women with exacerbation of cytomegalovirus infection during gestation. Cytomegalovirus infection was associated with a decrease in the content of reduced glutathione in erythrocytes and glutathione peroxidase, which leads to H...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-06, Vol.157 (2), p.278-281
Main Authors: Lutsenko, M. T., Andrievskaya, I. A., Kutepova, O. L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia
Anemia in pregnancy
Antioxidants
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cytomegalovirus
Cytomegalovirus infections
Cytomegalovirus Infections - blood
Cytomegalovirus Infections - physiopathology
Erythrocytes - metabolism
Fatty acids
Female
Glutathione - blood
Glutathione Peroxidase - blood
Glutathione Reductase - blood
Health aspects
Hemoglobin
Humans
Hydrogen Peroxide - blood
Internal Medicine
Laboratory Medicine
Pathology
Pregnancy
Pregnant women
Young Adult
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Summary:We studied factors infl uencing peripheral blood erythrocytes of pregnant women with exacerbation of cytomegalovirus infection during gestation. Cytomegalovirus infection was associated with a decrease in the content of reduced glutathione in erythrocytes and glutathione peroxidase, which leads to H 2 O 2 accumulation in the blood. Exacerbation of cytomegalovirus infection was associated with reduction of glutathione reductase and SOD activities. Erythrocyte antioxidant function and the peripheral blood discocyte count decreased. Accumulation of degenerative erythrocytes is fraught with the risk of anemia in pregnant women.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2544-7