Chlamydia Pneumoniae and Immunoinflammatory Reactions in an Unstable Atherosclerotic Plaque in Humans

Comparative study of the walls of the aorta, coronary artery, and a. basilaris detected for the first time intra- and extracellular depositions of Chlamydia pneumoniae in unstable atherosclerotic plaques. No chlamydia were detected in the intima of normal sites of the vascular wall and just negligib...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-06, Vol.159 (2), p.278-281
Main Authors: Pigarevskii, P. V., Mal’tseva, S. V., Snegova, V. A., Davydova, N. G., Guseva, V. A.
Format: Article
Language:English
Subjects:
Aged
Aorta - microbiology
Aorta - pathology
Atherosclerosis - microbiology
Atherosclerosis - pathology
Atherosclerotic plaque
B cells
Basilar Artery - microbiology
Basilar Artery - pathology
Biomedical and Life Sciences
Biomedicine
Cadaver
Cell Biology
Chlamydia
Chlamydophila pneumoniae
Chlamydophila pneumoniae - immunology
Chlamydophila pneumoniae - ultrastructure
Coronary Vessels - microbiology
Coronary Vessels - pathology
Histological Techniques
Humans
Internal Medicine
Laboratory Medicine
Male
Microscopy, Electron, Scanning
Middle Aged
Pathology
Pneumonia
T cells
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Summary:Comparative study of the walls of the aorta, coronary artery, and a. basilaris detected for the first time intra- and extracellular depositions of Chlamydia pneumoniae in unstable atherosclerotic plaques. No chlamydia were detected in the intima of normal sites of the vascular wall and just negligible levels thereof in stable atherosclerotic plaques. An unstable plaque with intra- and extracellular colonies was characterized by infiltration of the cap and intima adjacent to the atheromatous core with mononuclear cells, primarily T cells. These data suggested that Chlamydia pneumoniae could play an important role in the development of immunoinflammatory processes in the vascular wall and promote destabilization and progressive development of atherosclerotic plaques in humans.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2941-6