Factors of Th17 and Treg Lymphocyte Differentiation in Pulmonary Tuberculosis

In patients with infiltrative pulmonary tuberculosis, the increase in IL-6 secretion, the decrease in TGFβ production (in case of drug resistance of the causative agent), and unchanged level of IL-1β secretion by mononuclear leukocytes in vitro were associated with increased number of CD4 + CD161 +...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-06, Vol.159 (2), p.201-204
Main Authors: Kononova, T. E., Urazova, O. I., Novitskii, V. V., Kolobovnikova, Yu. V., Churina, E. G., Zakharova, P. A.
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
CD4 Antigens - metabolism
Cell Biology
Cell Differentiation - immunology
Drug resistance
Female
Forkhead Transcription Factors - metabolism
Humans
Interleukin-2 Receptor alpha Subunit - metabolism
Internal Medicine
Laboratory Medicine
Male
Middle Aged
Mycobacterium
NK Cell Lectin-Like Receptor Subfamily B - metabolism
Pathology
Pulmonary tuberculosis
Statistics, Nonparametric
T cells
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
Th17 Cells - immunology
Th17 Cells - metabolism
Transforming Growth Factor beta - immunology
Transforming growth factors
Tuberculosis, Pulmonary - blood
Tuberculosis, Pulmonary - immunology
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Summary:In patients with infiltrative pulmonary tuberculosis, the increase in IL-6 secretion, the decrease in TGFβ production (in case of drug resistance of the causative agent), and unchanged level of IL-1β secretion by mononuclear leukocytes in vitro were associated with increased number of CD4 + CD161 + IL-17A + Th17 lymphocytes in the peripheral blood. In patients with disseminated drug-resistant pulmonary tuberculosis, TGFβ hyperproduction promoted differentiation of CD4 + CD25 + FoxP3 + Treg lymphocytes with immunosuppressive activity.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2922-9