Role of Chlamydia in Multiple Sclerosis

• Published in: Bulletin of experimental biology and medicine 2015-09, Vol.159 (5), p.646-648
• Main Authors: Ivanova, M. V., Kolkova, N. I., Morgunova, E. Yu, Pashko, Yu. P., Zigangirova, N. A., Zakharova, M. N.
• Format: Article
• Language: English
• Subjects: Adult; Antibodies; Antibodies, Bacterial - blood; Antibodies, Bacterial - cerebrospinal fluid; Bacterial Typing Techniques; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Cell Biology; Chlamydia; Chlamydia infections; Chlamydia Infections - blood; Chlamydia Infections - cerebrospinal fluid; Chlamydia Infections - microbiology; Chlamydia Infections - pathology; Chlamydia trachomatis - isolation & purification; Chlamydia trachomatis - physiology; Chlamydophila pneumoniae; Chlamydophila pneumoniae - isolation & purification; Chlamydophila pneumoniae - physiology; DNA, Bacterial - blood; DNA, Bacterial - cerebrospinal fluid; Female; Humans; Immunoglobulin A - blood; Immunoglobulin A - cerebrospinal fluid; Immunoglobulin G - blood; Immunoglobulin G - cerebrospinal fluid; Immunoglobulin M - blood; Immunoglobulin M - cerebrospinal fluid; Internal Medicine; Laboratory Medicine; Male; Middle Aged; Multiple sclerosis; Multiple Sclerosis - blood; Multiple Sclerosis - cerebrospinal fluid; Multiple Sclerosis - microbiology; Multiple Sclerosis - pathology; Pathology; Pneumonia; Severity of Illness Index
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-015-3037-z

Chlamydia and antibodies to them were detected by serological, molecular biological, and culture methods in the sera and cerebrospinal fluid of patients with multiple sclerosis and in the reference groups of subjects without neurological diseases. Correlations between the agent presence in the biological fluids of patients and clinical characteristics of the disease were analyzed. C. pneumoniae were more incident in the biological liquids of patients with multiple sclerosis than in healthy volunteers. On the other hand, the incidence of the agent in the patients was not high and its presence did not correlate with the clinical manifestations. C. trachomatis was equally rare in the patients and volunteers. The studies indicated the existence of a group of patients infected by C. pneumoniae in the cohort of patients with multiple sclerosis, but the impact of this agent for the disease course remains unclear.