Efficacy of new leukocyte parameters versus serum C-reactive protein, procalcitonin, and interleukin-6 in the diagnosis of neonatal sepsis

• Published in: Pediatrics international 2016-02, Vol.58 (2), p.119-125
• Main Authors: Çelik, H. Tolga, Portakal, Oytun, Yiğit, Şule, Hasçelik, Gülşen, Korkmaz, Ayşe, Yurdakök, Murat
• Format: Article
• Language: English
• Subjects: C-reactive protein; C-Reactive Protein - metabolism; Calcitonin - blood; Conductivity; Cytokines; Diagnosis; Differential diagnosis; Female; Humans; Infant, Newborn; Infants; Interleukin 6; Interleukin-6 - blood; Leukocyte Count; leukocyte parameter; Male; Monocytes; neonatal sepsis; Neonatal Sepsis - diagnosis; Neonates; Neutrophils; Pediatrics; Peripheral blood; Predictive Value of Tests; Procalcitonin; Sensitivity and Specificity; Sepsis; Smear
• ISSN: 1328-8067; 1442-200X
• DOI: 10.1111/ped.12754

Background The aim of this study was to investigate and compare the efficacy of the new leukocyte parameters mean neutrophil and monocyte volume (MNV, MMV), conductivity (MNC, MMC), scattering (MNS, MMS) and volume distribution width (NDW, MDW) with serum C‐reactive protein (CRP), procalcitonin (PC) and interleukin (IL)‐6 in the diagnosis of neonatal sepsis. Methods A total of 227 newborns (132 boys, 95 girls) were analyzed. There were 116 infants in the sepsis group (proven sepsis, n = 40; clinical sepsis, n = 76) and 111 in the control group. Venous blood samples were collected from infants at the time of diagnosis and complete blood count, peripheral blood smear, blood cultures, CRP, PC, IL‐6 and MNV, MMV, MNC, MMC, MNS, MMS, NDW, and MDW were analyzed. Results MNV, NDW, MMV and, MDW were higher in infants with sepsis than in controls (P