Successful Unrelated Stem Cell Transplantation in an Infant With Congenital Acute Myelogenous Leukemia FAB M5 Showing Massive Cutaneous Infiltrations-A Challenging Multidisciplinary Approach

The multidisciplinary management of a male neonate presenting with congenital acute myelogenous leukemia of monoblastic phenotype is reported using conventional chemotherapy, high dose conditioning, and matched unrelated donor stem cell transplantation. These therapies were combined to add a graft v...

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Bibliographic Details
Published in:Pediatric blood & cancer 2016-01, Vol.63 (1), p.160-163
Main Authors: Lanz, Sofia, Schwinger, Wolfgang, Sovinz, Petra, Lackner, Herwig, Resch, Bernhard, Urlesberger, Berndt, Sipurzynski, Sabine, Urban, Christian
Format: Article
Language:English
Subjects:
allogeneic stem cell transplantation
congenital acute myelogenous leukemia
Graft vs Leukemia Effect
Hematology
Humans
infant
Infant, Newborn
Leukemia, Myeloid, Acute - congenital
Leukemia, Myeloid, Acute - pathology
Leukemia, Myeloid, Acute - therapy
Male
Oncology
Patient Care Team
Pediatrics
Stem Cell Transplantation
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Summary:The multidisciplinary management of a male neonate presenting with congenital acute myelogenous leukemia of monoblastic phenotype is reported using conventional chemotherapy, high dose conditioning, and matched unrelated donor stem cell transplantation. These therapies were combined to add a graft versus leukemia effect to the treatment. Although chimerism studies showed a decrease of donor white blood cells, T‐cells remained stable of allogeneic origin. We hypothesize that a continuous graft versus leukemia effect results in minimal residual disease negativity for now more than 18 months since stem cell transplantation. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.25703