Mycoplasma pneumoniae infection induces asthma onset

After Edward Jenner (1798) showed the benefits of the immune response and how it can be modulated, Richet and Portier (1902) demonstrated that not all immune responses are beneficial. [...]the opposing concepts of prophylaxis and anaphylaxis arose, with an overreaction to normally harmless environme...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2016-04, Vol.137 (4), p.1024-1025
Main Authors: Giavina-Bianchi, Pedro, MD, PhD, Kalil, Jorge, MD, PhD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antibiotics
Antigens
Asthma
Asthma - microbiology
Bacterial infections
Cloning
Disease
Female
Food allergies
Genotype & phenotype
Humans
Hygiene
Hypotheses
Immune system
Infections
Inflammation
Male
Pneumonia, Mycoplasma - complications
Siblings
Studies
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Summary:After Edward Jenner (1798) showed the benefits of the immune response and how it can be modulated, Richet and Portier (1902) demonstrated that not all immune responses are beneficial. [...]the opposing concepts of prophylaxis and anaphylaxis arose, with an overreaction to normally harmless environmental antigens in the latter. Dysbiosis, which is characterized by alterations in microbiota composition and function, has been implicated in several inflammatory and immunologic diseases, including allergies. [...]modulation of the microbiota can be used to prevent and treat disease.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2015.11.011