Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp. GS-17

Based on the chemical analysis and targeted bioactivity screening, a new polyketide glycoside, myrothecoside, was isolated from a terrestrial halotolerant fungus, Myrothecium sp. GS‐17. The structure of myrothecoside was elucidated on the basis of extensive spectroscopic analysis including 1D‐ and 2...

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Bibliographic Details
Published in:Helvetica chimica acta 2016-03, Vol.99 (3), p.215-219
Main Authors: Zhang, Songya, Zhu, Jing, Liu, Tao, Samra, Suzan, Pan, Huaqi, Bai, Jiao, Hua, Huiming, Bechthold, Andreas
Format: Article
Language:English
Subjects:
Antibacterial activity
Fungi
Fusarium oxysporum
Glycosylated polyketides
Myrothecium
Rhizoctonia solani
Secondary metabolites
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Summary:Based on the chemical analysis and targeted bioactivity screening, a new polyketide glycoside, myrothecoside, was isolated from a terrestrial halotolerant fungus, Myrothecium sp. GS‐17. The structure of myrothecoside was elucidated on the basis of extensive spectroscopic analysis including 1D‐ and 2D‐NMR (1H,1H‐COSY, HSQC, HMBC, and NOESY) experiments, combined with mass spectroscopic data and physicochemical properties. This compound exhibited weak cytotoxicity against human leukemia (HL‐60) cancer cell with an IG50 value of 63.61 μm, and also antifungal activities against plant pathogenic fungi Rhizoctonia solani and Fusarium oxysporum using standard agar diffusion tests at 20 μg/disk.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201500218