Small Molecules Take A Big Step Against Clostridium difficile

Effective treatment of Clostridium difficile infections demands a shift away from antibiotics towards toxin-neutralizing agents. Work by Bender et al. , using a drug that attenuates toxin action in vivo without affecting bacterial survival, demonstrates the exciting potential of small molecules as a...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2015-12, Vol.23 (12), p.746-748
Main Authors: Beilhartz, Greg L, Tam, John, Melnyk, Roman A
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - therapeutic use
Clostridium difficile
Clostridium difficile - isolation & purification
Clostridium Infections - drug therapy
ebselen
inhibitor
Internal Medicine
small molecule
TcdB
Virulence - drug effects
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Summary:Effective treatment of Clostridium difficile infections demands a shift away from antibiotics towards toxin-neutralizing agents. Work by Bender et al. , using a drug that attenuates toxin action in vivo without affecting bacterial survival, demonstrates the exciting potential of small molecules as a new modality in the fight against C. difficile.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2015.10.009