Outcomes of Patients at Estimated Low, Intermediate, and High Risk Undergoing Transcatheter Aortic Valve Implantation for Aortic Stenosis

• Published in: The American journal of cardiology 2015-12, Vol.116 (12), p.1916-1922
• Main Authors: Barbash, Israel Moshe, MD, Finkelstein, Ariel, MD, Barsheshet, Alon, MD, Segev, Amit, MD, Steinvil, Arie, MD, Assali, Abid, MD, Ben Gal, Yanai, MD, Vaknin Assa, Hana, MD, Fefer, Paul, MD, Sagie, Alex, MD, Guetta, Victor, MD, Kornowski, Ran, MD
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Aortic Valve Stenosis - mortality; Aortic Valve Stenosis - surgery; Cardiovascular; Female; Follow-Up Studies; Heart attacks; Hospitalization; Hospitals; Humans; Israel - epidemiology; Laboratories; Male; Mortality; Ostomy; Patients; Physicians; Prospective Studies; Pulmonary arteries; Risk Assessment - methods; Risk Factors; Stroke; Studies; Success; Survival Rate - trends; Time Factors; Transcatheter Aortic Valve Replacement; Treatment Outcome; Variables
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2015.09.030

Intermediate- or low-risk patients with severe aortic stenosis were excluded from earlier transcatheter aortic valve implantation (TAVI) clinical trials; however, they are already being treated by TAVI despite a lack of data regarding the safety and efficacy in these patients. We aimed to assess the safety and efficacy of TAVI in patients at intermediate or low risk. Patients undergoing TAVI during 2008 to 2014 were included into a shared database (n = 1,327). Procedural outcomes were adjudicated according to Valve Academic Research Consortium 2 definitions. Patients were stratified according to their Society of Thoracic Surgeons (STS) score into 3 groups: high (STS ≥8, n = 223, 17%), intermediate (STS 4 to 8; n = 496, 38%), or low risk (STS