Crucial role of astrocytes in temporal lobe epilepsy

Highlights • Astrocytes sense and respond to synaptic activity. • Gap junction coupling allows these cells to redistribute K+ ions and glutamate. • Tissues from epilepsy patients and animal models display dysfunctional astrocytes. • Astrocytes represent new targets for anti-epileptogenic therapies....

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Bibliographic Details
Published in:Neuroscience 2016-05, Vol.323, p.157-169
Main Authors: Steinhäuser, C, Grunnet, M, Carmignoto, G
Format: Article
Language:English
Subjects:
adenosine kinase
Animals
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
antiepileptic drugs
astrocyte
Astrocytes - drug effects
Astrocytes - metabolism
Brain - drug effects
Brain - metabolism
connexin
Epilepsy, Temporal Lobe - drug therapy
Epilepsy, Temporal Lobe - metabolism
Humans
Kir channel
Neurology
water channel
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Summary:Highlights • Astrocytes sense and respond to synaptic activity. • Gap junction coupling allows these cells to redistribute K+ ions and glutamate. • Tissues from epilepsy patients and animal models display dysfunctional astrocytes. • Astrocytes represent new targets for anti-epileptogenic therapies.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.12.047