Influenza Nucleoprotein: Promising Target for Antiviral Chemotherapy

In the search for new anti-influenza agents, the viral polymerase has often been targeted due to the involvement of multiple conserved proteins and their distinct activities. Polymerase associates with each of the eight singled-stranded negative-sense viral RNA segments. These transcriptionally comp...

Full description

Saved in:
Bibliographic Details
Published in:Antiviral Chemistry and Chemotherapy 2013-06, Vol.23 (3), p.77-91
Main Authors: Cianci, Christopher, Gerritz, Samuel W, Deminie, Carol, Krystal, Mark
Format: Article
Language:English
Subjects:
Alphainfluenzavirus - drug effects
Alphainfluenzavirus - metabolism
Amides - chemistry
Amides - pharmacology
Animals
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Antiviral drugs
Chemotherapy
Drug development
Drug Discovery - methods
Genomes
Humans
Influenza
Influenza, Human - drug therapy
Influenza, Human - virology
Models, Molecular
Molecular Targeted Therapy - methods
Nucleoproteins - chemistry
Nucleoproteins - metabolism
Orthomyxoviridae Infections - drug therapy
Orthomyxoviridae Infections - virology
Piperazine
Piperazines - chemistry
Piperazines - pharmacology
Ribonucleic acid
RNA
Structure-function relationships
Transcription
Viral Proteins - chemistry
Viral Proteins - metabolism
Virus Replication - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the search for new anti-influenza agents, the viral polymerase has often been targeted due to the involvement of multiple conserved proteins and their distinct activities. Polymerase associates with each of the eight singled-stranded negative-sense viral RNA segments. These transcriptionally competent segments are coated with multiple copies of nucleoprotein (NP) to form the ribonucleoprotein. NP is an abundant essential protein, possessing operative and structural functions, and participating in genome organization, nuclear trafficking and RNA transcription and replication. This review examines the NP structure and function, and explores NP as an emerging target for anti-influenza drug development, focusing on recently discovered aryl piperazine amide inhibitor chemotypes.
ISSN:2040-2066
0956-3202
2040-2066
DOI:10.3851/IMP2235