Ataxin-1 regulates proliferation of hippocampal neural precursors

Highlights • Atxn1−/− mice have reduced adult hippocampal neurogenesis. • Atxn1−/− hippocampal neural precursor cells (NPCs) proliferate less in vitro. • Transfection of mutant ATXN1[82Q] into wild-type NPCs inhibits their proliferation.

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Bibliographic Details
Published in:Neuroscience 2016-05, Vol.322, p.54-65
Main Authors: Asher, M, Johnson, A, Zecevic, B, Pease, D, Cvetanovic, M
Format: Article
Language:English
Subjects:
adult hippocampal neurogenesis
Animals
ATAXIN-1
Ataxin-1 - genetics
Ataxin-1 - metabolism
Cell Proliferation - physiology
Cells, Cultured
Cerebellum - cytology
Cerebellum - physiology
DNA Repeat Expansion
Female
Hippocampus - cytology
Hippocampus - physiology
Male
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Knockout
neural precursor cells
Neural Stem Cells - cytology
Neural Stem Cells - physiology
Neurogenesis - physiology
Neurology
RNA, Messenger - metabolism
SCA1
Spinocerebellar Ataxias
Transfection
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Description
Summary:Highlights • Atxn1−/− mice have reduced adult hippocampal neurogenesis. • Atxn1−/− hippocampal neural precursor cells (NPCs) proliferate less in vitro. • Transfection of mutant ATXN1[82Q] into wild-type NPCs inhibits their proliferation.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.02.011