Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo

Highlights • Impact of gle1 depletion on zebrafish development. • Role of RNA-binding protein gle1 in motor neuron and Schwann cell development. • Schwann cell may have a role in gle1-linked LCCS1pathology.

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Bibliographic Details
Published in:Neuroscience 2016-05, Vol.322, p.287-297
Main Authors: Seytanoglu, A, Alsomali, N.I, Valori, C.F, McGown, A, Kim, H.R, Ning, K, Ramesh, T, Sharrack, B, Wood, J.D, Azzouz, M
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified
Arthrogryposis
Cell Differentiation - physiology
Cell Proliferation - physiology
Danio rerio
Eye - embryology
Eye - pathology
Immunohistochemistry
In Situ Hybridization
In Situ Nick-End Labeling
lethal congenital contracture syndrome 1
Microscopy, Electron, Transmission
motor neuron
Motor Neurons - pathology
Motor Neurons - physiology
Myelin Basic Protein - metabolism
Neural Stem Cells - pathology
Neural Stem Cells - physiology
Neurology
Rhombencephalon - embryology
Rhombencephalon - pathology
RNA-Binding Proteins - genetics
Schwann cell development
Schwann Cells - pathology
Schwann Cells - physiology
Survival Analysis
Zebrafish - embryology
zebrafish model
Zebrafish Proteins - deficiency
Zebrafish Proteins - genetics
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Description
Summary:Highlights • Impact of gle1 depletion on zebrafish development. • Role of RNA-binding protein gle1 in motor neuron and Schwann cell development. • Schwann cell may have a role in gle1-linked LCCS1pathology.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.02.039