Molecular Factors of Cytokine-Dependent Activation of T Cells in Pulmonary Tuberculosis

The parameters characterizing antituberculous immune response at the stage of cytokinedependent activation of T cells were analyzed in 90 patients with pulmonary tuberculosis before etiotropic therapy. Immunophenotyping of T cells for IL-12Rβ 2 , WSX-1, and gp130 surface markers and T-bet intracellu...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-07, Vol.159 (3), p.390-392
Main Authors: Esimova, I. E., Urazova, O. I., Ignatova, M. S., Novitskii, V. V., Kolobovnikova, Yu. V.
Format: Article
Language:English
Subjects:
Adult
Analysis
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cytokines - metabolism
Female
Humans
Immunophenotyping
Interleukins
Interleukins - metabolism
Internal Medicine
Laboratory Medicine
Male
Middle Aged
Mycobacterium
Pathology
Pulmonary tuberculosis
T cells
T-Lymphocytes - metabolism
Tuberculosis, Pulmonary - metabolism
Young Adult
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Summary:The parameters characterizing antituberculous immune response at the stage of cytokinedependent activation of T cells were analyzed in 90 patients with pulmonary tuberculosis before etiotropic therapy. Immunophenotyping of T cells for IL-12Rβ 2 , WSX-1, and gp130 surface markers and T-bet intracellular transcription factor was carried out after specific IL-12/IL-27 induction of cells in vitro . An increase in the counts of CD3 + T-bet + , CD3 + IL-12Rβ 2 + , and CD3 + WSX-1 + gp130 + cells and the level of T cells with high expression of WSX-1 inhibitory molecule (CD3 + WSX-1 hi+ gp130 − and CD3 + WSX-1 hi+ gp130 + ) was detected. The type of disorders in the inductive stage of antituberculous immune response did not depend on the clinical form of disease.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2971-0