Physiological Parameters of Macaca Fascicularis Immunized with Anti-Rubella Vaccine with Germanium-Based Adjuvants

Clinical status, hematological and biochemical parameters, and allergenic activity of organogermanium compounds used as adjuvants in complex with preparation from Orlov rubella virus vaccine strain and reference commercial anti-rubella vaccine based on Wistar RA 27/3 strain were studied on Macaca fa...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-05, Vol.157 (1), p.81-84
Main Authors: Karal-ogly, D. D., Agrba, V. Z., Lavrent’eva, I. N., Ambrosov, I. V., Matelo, S. K., Chuguev, Yu. P., Gvaramiya, I. A., Gvozdik, T. E., Mukhametzyanova, E. I.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - chemistry
Animals
Antibodies, Viral - blood
Biomedical and Life Sciences
Biomedicine
Blood Cell Count
Cell Biology
Drug Evaluation, Preclinical
Female
Germanium - chemistry
Germanium - immunology
Health aspects
Immunization
Immunoglobulin E - blood
Internal Medicine
Laboratory Medicine
Macaca fascicularis
Male
Measles-mumps-rubella vaccine
Organometallic Compounds - administration & dosage
Organometallic Compounds - chemistry
Organometallic Compounds - immunology
Pathology
Primatology
Rats
Rubella
Rubella - blood
Rubella - immunology
Rubella - prevention & control
Rubella - virology
Rubella Vaccine - administration & dosage
Rubella Vaccine - biosynthesis
Rubella Vaccine - immunology
Rubella virus
Rubella virus - immunology
Vaccination
Vaccines
Vaccines, Attenuated
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Description
Summary:Clinical status, hematological and biochemical parameters, and allergenic activity of organogermanium compounds used as adjuvants in complex with preparation from Orlov rubella virus vaccine strain and reference commercial anti-rubella vaccine based on Wistar RA 27/3 strain were studied on Macaca fascilcularis of both genders. Physiological parameters of monkeys immunized with the Russian and foreign rubella virus vaccine strains with and without adjuvants did not differ. The adjuvants were inessential for the safety of vaccines (absence of toxicity, reactogenic activity, or allergenic activity) in preclinical studies on lower primates.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2497-x