Anthracyclines potentiate anti-tumor immunity: A new opportunity for chemoimmunotherapy

Highlights • Anthracyclines exhibit stronger efficacy and have a vital role in anticancer therapy. • Anthracyclines have the capacity to relieve tumor induced immunosuppression and restore anticancer immune responses. • Clearly, sporadic but impressive trials of anthracycline-based chemoimmunotherap...

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Bibliographic Details
Published in:Cancer letters 2015-12, Vol.369 (2), p.331-335
Main Authors: Zhang, Zhigang, Yu, Xiuyan, Wang, Zhen, Wu, Pin, Huang, Jian
Format: Article
Language:English
Subjects:
Anthracyclines
Anthracyclines - immunology
Anthracyclines - therapeutic use
Antibiotics, Antineoplastic - pharmacology
Anticancer immunity
Antigens
Apoptosis
Breast cancer
Cancer therapies
Chemoimmunotherapy
Chemotherapy
Clinical trials
Conflicts of interest
Cytokines
Cytotoxicity
Dendritic cells
Deoxyribonucleic acid
DNA
Doxorubicin
Doxorubicin - pharmacology
Gene expression
Hematology, Oncology and Palliative Medicine
Humans
Immunomodulation
Immunotherapy
Lymphocytes
Metastasis
Ovarian cancer
Streptomyces
Streptomyces peucetius
Tumor Microenvironment
Tumors
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Summary:Highlights • Anthracyclines exhibit stronger efficacy and have a vital role in anticancer therapy. • Anthracyclines have the capacity to relieve tumor induced immunosuppression and restore anticancer immune responses. • Clearly, sporadic but impressive trials of anthracycline-based chemoimmunotherapy regimens were starting to emerge.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.10.002