Effect of Glycolipid Rhodococcus Biosurfactant on Secretory Activity of Neutrophils In Vitro

Glycolipid biosurfactant synthesized by nonpathogenic strain Rhodococcus ruber IEGM231 modulated the production of ROS and IL-8 by peripheral blood neutrophils in spontaneous and stimulated cultures. Secretion of IL-1β и TNF-α by neutrophils in the presence of biosurfactant changed insignifi cantly....

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-06, Vol.157 (2), p.238-242
Main Authors: Baeva, T. A., Gein, S. V., Kuyukina, M. S., Ivshina, I. B., Kochina, O. A., Chereshnev, V. A.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cells, Cultured
Glycolipids - chemistry
Glycolipids - pharmacology
Humans
Interleukin-8 - metabolism
Internal Medicine
Laboratory Medicine
Lipids
Neutrophils - drug effects
Neutrophils - metabolism
Pathology
Reactive Oxygen Species - metabolism
Rhodococcus
Rhodococcus - chemistry
Rhodococcus ruber
Sugars
Surface-Active Agents - pharmacology
Tumor Necrosis Factor-alpha - metabolism
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Summary:Glycolipid biosurfactant synthesized by nonpathogenic strain Rhodococcus ruber IEGM231 modulated the production of ROS and IL-8 by peripheral blood neutrophils in spontaneous and stimulated cultures. Secretion of IL-1β и TNF-α by neutrophils in the presence of biosurfactant changed insignifi cantly.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2534-9