Effect of polyclonal activators on cytokine production by blood cells and by malignant breast cancer cells

The production of cytokines by peripheral blood cells and biopsy specimens of tumors stimulated by polyclonal activators (PAs) was evaluated in 34 patients with invasive ductal breast carcinoma using enzyme-linked immunosorbent assay (ELISA). Positive correlation between the stimulation index of pol...

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Bibliographic Details
Published in:Doklady. Biological sciences 2016, Vol.466 (1), p.45-47
Main Authors: Kunts, T. A., Karpukhina, K. V., Mikhaylova, E. S., Marinkin, I. O., Varaksin, N. A., Autenshlyus, A. I., Lyakhovich, V. V.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Blood Cells - metabolism
Blood Cells - pathology
Carcinogenesis - genetics
Carcinoma, Ductal, Breast - blood
Carcinoma, Ductal, Breast - genetics
Carcinoma, Ductal, Breast - pathology
Cell Biology
Concanavalin A - pharmacology
Enzyme-Linked Immunosorbent Assay
Evolutionary Biology
Female
Granulocyte Colony-Stimulating Factor - blood
Granulocyte Colony-Stimulating Factor - genetics
Humans
Interleukin-18 - blood
Interleukin-18 - genetics
Interleukin-6 - blood
Interleukin-6 - genetics
Life Sciences
Lipopolysaccharides - pharmacology
Mitosis - genetics
Neoplasm Invasiveness - genetics
Neoplasm Metastasis
Neovascularization, Pathologic - genetics
Neovascularization, Pathologic - pathology
Phytohemagglutinins - pharmacology
Plant Sciences
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Summary:The production of cytokines by peripheral blood cells and biopsy specimens of tumors stimulated by polyclonal activators (PAs) was evaluated in 34 patients with invasive ductal breast carcinoma using enzyme-linked immunosorbent assay (ELISA). Positive correlation between the stimulation index of polyclonal activators (SIPA) for IL-18 production by the tumor and the relative content of poorly differentiated cells was revealed. The latter, in turn, was positively correlated with the numbers of normal and pathologic mitoses and the degree of malignancy. Cancer cells can produce IL-18, which is involved in the process of angiogenesis, stimulates invasion and metastasis. Decrease in SIPA for the production of IL-6 and GCSF by peripheral blood cells could serve as an indicator of malignant progression in invasive ductal breast carcinoma.
ISSN:0012-4966
1608-3105
DOI:10.1134/S0012496616010026