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Effect of polyclonal activators on cytokine production by blood cells and by malignant breast cancer cells
The production of cytokines by peripheral blood cells and biopsy specimens of tumors stimulated by polyclonal activators (PAs) was evaluated in 34 patients with invasive ductal breast carcinoma using enzyme-linked immunosorbent assay (ELISA). Positive correlation between the stimulation index of pol...
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| Published in: | Doklady. Biological sciences 2016, Vol.466 (1), p.45-47 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c3206-742cf432e562e633839f8be9da2d84d13be9da89718fe2f7f713fa10300d4d183 |
| container_end_page | 47 |
| container_issue | 1 |
| container_start_page | 45 |
| container_title | Doklady. Biological sciences |
| container_volume | 466 |
| creator | Kunts, T. A. Karpukhina, K. V. Mikhaylova, E. S. Marinkin, I. O. Varaksin, N. A. Autenshlyus, A. I. Lyakhovich, V. V. |
| description | The production of cytokines by peripheral blood cells and biopsy specimens of tumors stimulated by polyclonal activators (PAs) was evaluated in 34 patients with invasive ductal breast carcinoma using enzyme-linked immunosorbent assay (ELISA). Positive correlation between the stimulation index of polyclonal activators (SIPA) for IL-18 production by the tumor and the relative content of poorly differentiated cells was revealed. The latter, in turn, was positively correlated with the numbers of normal and pathologic mitoses and the degree of malignancy. Cancer cells can produce IL-18, which is involved in the process of angiogenesis, stimulates invasion and metastasis. Decrease in SIPA for the production of IL-6 and GCSF by peripheral blood cells could serve as an indicator of malignant progression in invasive ductal breast carcinoma. |
| doi_str_mv | 10.1134/S0012496616010026 |
| format | article |
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A.</creatorcontrib><creatorcontrib>Autenshlyus, A. I.</creatorcontrib><creatorcontrib>Lyakhovich, V. V.</creatorcontrib><title>Effect of polyclonal activators on cytokine production by blood cells and by malignant breast cancer cells</title><title>Doklady. Biological sciences</title><addtitle>Dokl Biol Sci</addtitle><addtitle>Dokl Biol Sci</addtitle><description>The production of cytokines by peripheral blood cells and biopsy specimens of tumors stimulated by polyclonal activators (PAs) was evaluated in 34 patients with invasive ductal breast carcinoma using enzyme-linked immunosorbent assay (ELISA). Positive correlation between the stimulation index of polyclonal activators (SIPA) for IL-18 production by the tumor and the relative content of poorly differentiated cells was revealed. The latter, in turn, was positively correlated with the numbers of normal and pathologic mitoses and the degree of malignancy. Cancer cells can produce IL-18, which is involved in the process of angiogenesis, stimulates invasion and metastasis. Decrease in SIPA for the production of IL-6 and GCSF by peripheral blood cells could serve as an indicator of malignant progression in invasive ductal breast carcinoma.</description><subject>Biomedical and Life Sciences</subject><subject>Blood Cells - metabolism</subject><subject>Blood Cells - pathology</subject><subject>Carcinogenesis - genetics</subject><subject>Carcinoma, Ductal, Breast - blood</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Cell Biology</subject><subject>Concanavalin A - pharmacology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Evolutionary Biology</subject><subject>Female</subject><subject>Granulocyte Colony-Stimulating Factor - blood</subject><subject>Granulocyte Colony-Stimulating Factor - genetics</subject><subject>Humans</subject><subject>Interleukin-18 - blood</subject><subject>Interleukin-18 - genetics</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - genetics</subject><subject>Life Sciences</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Mitosis - genetics</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasm Metastasis</subject><subject>Neovascularization, Pathologic - genetics</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>Plant Sciences</subject><issn>0012-4966</issn><issn>1608-3105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkUtLxDAUhYMoOj5-gBsJuHFTvUnaJF2KjA8QXKjrkqbJ0LGTjEkrzL83dUYRRXCVm3u-e3LJQeiYwDkhLL94BCA0LzknHAgA5VtokkqZMQLFNpqMcjbqe2g_xjmkOwi2i_aoAEqYgAmaT601usfe4qXvVrrzTnVY6b59U70PEXuH9ar3L60zeBl8MyQp9eoVrjvvG6xN10WsXDO2FqprZ065HtfBqNhjrZw2YQ0doh2rumiONucBer6ePl3dZvcPN3dXl_eZZhR4JnKqbc6oKTg1nDHJSitrUzaKNjJvCPuoZSmItIZaYQVhVhFgAE2SJTtAZ2vftO7rYGJfLdo4bqCc8UOsiJAFzRkr_oMKAaIo5Yie_kDnfgjpsz4oTktekDxRZE3p4GMMxlbL0C5UWFUEqjGz6ldmaeZk4zzUC9N8TXyGlAC6BmKS3MyEb0__6foOqLSfWw</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Kunts, T. 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Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kunts, T. A.</au><au>Karpukhina, K. V.</au><au>Mikhaylova, E. S.</au><au>Marinkin, I. O.</au><au>Varaksin, N. A.</au><au>Autenshlyus, A. I.</au><au>Lyakhovich, V. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of polyclonal activators on cytokine production by blood cells and by malignant breast cancer cells</atitle><jtitle>Doklady. Biological sciences</jtitle><stitle>Dokl Biol Sci</stitle><addtitle>Dokl Biol Sci</addtitle><date>2016</date><risdate>2016</risdate><volume>466</volume><issue>1</issue><spage>45</spage><epage>47</epage><pages>45-47</pages><issn>0012-4966</issn><eissn>1608-3105</eissn><abstract>The production of cytokines by peripheral blood cells and biopsy specimens of tumors stimulated by polyclonal activators (PAs) was evaluated in 34 patients with invasive ductal breast carcinoma using enzyme-linked immunosorbent assay (ELISA). Positive correlation between the stimulation index of polyclonal activators (SIPA) for IL-18 production by the tumor and the relative content of poorly differentiated cells was revealed. The latter, in turn, was positively correlated with the numbers of normal and pathologic mitoses and the degree of malignancy. Cancer cells can produce IL-18, which is involved in the process of angiogenesis, stimulates invasion and metastasis. Decrease in SIPA for the production of IL-6 and GCSF by peripheral blood cells could serve as an indicator of malignant progression in invasive ductal breast carcinoma.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>27021370</pmid><doi>10.1134/S0012496616010026</doi><tpages>3</tpages></addata></record> |
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| subjects | Biomedical and Life Sciences Blood Cells - metabolism Blood Cells - pathology Carcinogenesis - genetics Carcinoma, Ductal, Breast - blood Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology Cell Biology Concanavalin A - pharmacology Enzyme-Linked Immunosorbent Assay Evolutionary Biology Female Granulocyte Colony-Stimulating Factor - blood Granulocyte Colony-Stimulating Factor - genetics Humans Interleukin-18 - blood Interleukin-18 - genetics Interleukin-6 - blood Interleukin-6 - genetics Life Sciences Lipopolysaccharides - pharmacology Mitosis - genetics Neoplasm Invasiveness - genetics Neoplasm Metastasis Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Phytohemagglutinins - pharmacology Plant Sciences |
| title | Effect of polyclonal activators on cytokine production by blood cells and by malignant breast cancer cells |
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