Functional Activity of Th-17 Lymphocytes in Pulmonary Tuberculosis

Increased content of CD4 + CD161 + IL-17A + Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug-resistant). The elevated content of Th17 cells in pul...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-04, Vol.156 (6), p.743-745
Main Authors: Kononova, T. E., Urazova, O. I., Novitskii, V. V., Churina, E. G., Kolobovnikova, Yu. V., Ignatov, M. V., Zakharova, P. A., Pechenova, O. V.
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
CD4 Antigens - metabolism
Cell Biology
Cells, Cultured
Female
Humans
Interleukin-17 - metabolism
Interleukin-22
Interleukins - metabolism
Internal Medicine
Laboratory Medicine
Lymphocytes
Male
Middle Aged
Mycobacterium
Mycobacterium tuberculosis - immunology
NK Cell Lectin-Like Receptor Subfamily B - metabolism
Pathology
Pulmonary tuberculosis
Th17 Cells - immunology
Tuberculosis, Pulmonary - immunology
Young Adult
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Summary:Increased content of CD4 + CD161 + IL-17A + Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug-resistant). The elevated content of Th17 cells in pulmonary tuberculosis is associated with hypersecretion of Th17-associated cytokines IL-17A and IL-22 in vitro that was most pronounced (in case of IL-17A) in patients with disseminated pulmonary tuberculosis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2438-8