Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging

Highlights • Specific computerised tasks were designed to induce co-activation of target areas. • A protocol of cognitive stimulation was devised to stimulate the default-mode network. • Voxel-based correlational methods supported task validity and appropriateness. • Increases in network connectivit...

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Bibliographic Details
Published in:Brain research bulletin 2016-03, Vol.121, p.26-41
Main Authors: De Marco, Matteo, Meneghello, Francesca, Duzzi, Davide, Rigon, Jessica, Pilosio, Cristina, Venneri, Annalena
Format: Article
Language:English
Subjects:
Aged
Aging - physiology
Alzheimer’s disease
Brain - diagnostic imaging
Brain - physiology
Brain Mapping
Brain networks
Cognition - physiology
Female
fMRI
Healthy Volunteers
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Mild cognitive impairment
Models, Neurological
Neural Pathways - diagnostic imaging
Neurology
Neuropsychological Tests
Resting state
Teaching
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Summary:Highlights • Specific computerised tasks were designed to induce co-activation of target areas. • A protocol of cognitive stimulation was devised to stimulate the default-mode network. • Voxel-based correlational methods supported task validity and appropriateness. • Increases in network connectivity were found in the experimental group. • Network-based stimulation might be a therapeutical avenue to boost connectivity in neurodegeneration.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2015.12.001