Probiotics in functional bowel disorders

Abstract Functional bowel disorders (FBDs) are the most common gastrointestinal (GI) disorders seen by gastroenterologists and primary care physicians. The disorders affect patients functioning and quality of life (QOL) and are associated with significant healthcare burden. The current theory regard...

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Bibliographic Details
Published in:Baillière's best practice & research. Clinical gastroenterology 2016-02, Vol.30 (1), p.89-97
Main Authors: Hod, Keren, PhD, Ringel, Yehuda, MD
Format: Article
Language:English
Subjects:
Antibiotics
Brain research
Clinical trials
Constipation
Functional bowel disorders
Gastroenterology and Hepatology
Gastrointestinal Microbiome - physiology
Gastrointestinal Tract - microbiology
Humans
Intestinal mocrobiota
Irritable bowel syndrome
Irritable Bowel Syndrome - microbiology
Irritable Bowel Syndrome - physiopathology
Irritable Bowel Syndrome - therapy
Microorganisms
Motility
Pain
Probiotics
Probiotics - therapeutic use
Quality
Studies
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Summary:Abstract Functional bowel disorders (FBDs) are the most common gastrointestinal (GI) disorders seen by gastroenterologists and primary care physicians. The disorders affect patients functioning and quality of life (QOL) and are associated with significant healthcare burden. The current theory regarding the development of FBDs suggests brain-gut axis dysfunctions associated abnormal GI motility and sensation. Recent data suggest that alterations in the intestinal microbiota may have a role in the pathogenesis of FBDs; or at least have the potential to affect intestinal functions that are thought to be relevant to the development of functional GI symptoms. This has led to growing interest of healthcare providers and patients in targeting the intestinal microbiota for the treatment of FBDs. In this article we discuss the potential role probiotic interventions in the treatment of FBDs. We review the evidence from pre-clinical and clinical studies and discuss the current recommendations for the use of probiotics for FBDs in clinical practice.
ISSN:1521-6918
1532-1916
DOI:10.1016/j.bpg.2016.01.003