Green tea compound epigallo-catechin-3-gallate (EGCG) increases neuronal survival in adult hippocampal neurogenesis in vivo and in vitro

Highlights • EGCG favors the survival of newborn neurons in the hippocampus. • EGCG is proneurogenic upon adult hippocampal precursor cells in culture. • EGCG might act through phospho-Akt.

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Bibliographic Details
Published in:Neuroscience 2016-05, Vol.322, p.208-220
Main Authors: Ortiz-López, L, Márquez-Valadez, B, Gómez-Sánchez, A, Silva-Lucero, M.D.C, Torres-Pérez, M, Téllez-Ballesteros, R.I, Ichwan, M, Meraz-Ríos, M.A, Kempermann, G, Ramírez-Rodríguez, G.B
Format: Article
Language:English
Subjects:
adult neurogenesis
Animals
Camellia sinensis
Catechin - analogs & derivatives
Catechin - chemistry
Catechin - pharmacology
Cell Survival - drug effects
Cell Survival - physiology
Cells, Cultured
Dose-Response Relationship, Drug
EGCG
hippocampus
Hippocampus - drug effects
Hippocampus - physiology
Male
Mice, Inbred BALB C
Microtubule-Associated Proteins - metabolism
Neural Stem Cells - drug effects
Neural Stem Cells - physiology
Neurogenesis - drug effects
Neurogenesis - physiology
Neurology
Neurons - drug effects
Neurons - physiology
Neuropeptides - metabolism
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacology
nutrition
Phosphatidylinositol 3-Kinases - metabolism
PI3K-Akt
Proto-Oncogene Proteins c-akt - metabolism
survival
Tea - chemistry
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Description
Summary:Highlights • EGCG favors the survival of newborn neurons in the hippocampus. • EGCG is proneurogenic upon adult hippocampal precursor cells in culture. • EGCG might act through phospho-Akt.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.02.040