Dexras1 a unique ras-GTPase interacts with NMDA receptor activity and provides a novel dissociation between anxiety, working memory and sensory gating

Highlights • A deletion of Dexras1 coupled to NMDAR showed no impact on basal anxiety and depression-like levels. • NDMA receptor subunit2A expression was increased in Dexras1 knockout mice. • Dexras1 knockout mice only exhibited an increase in pre-pulse inhibition.

Saved in:
Bibliographic Details
Published in:Neuroscience 2016-05, Vol.322, p.408-415
Main Authors: Carlson, G.C, Lin, R.E, Chen, Y, Brookshire, B.R, White, R.S, Lucki, I, Siegel, S.J, Kim, S.F
Format: Article
Language:English
Subjects:
Animals
Anxiety Disorders - metabolism
GTPases
learning and memory
Maze Learning - physiology
Memory, Episodic
Memory, Short-Term - physiology
Mice, Inbred C57BL
Mice, Knockout
Motor Activity - physiology
Neurology
NMDA
prepulse inhibition
Prepulse Inhibition - physiology
ras Proteins - genetics
ras Proteins - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
Recognition (Psychology) - physiology
sensory
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • A deletion of Dexras1 coupled to NMDAR showed no impact on basal anxiety and depression-like levels. • NDMA receptor subunit2A expression was increased in Dexras1 knockout mice. • Dexras1 knockout mice only exhibited an increase in pre-pulse inhibition.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.02.063