sHLA-G1 and HLA-G5 levels are decreased in Tunisian women with multiple abortion

Abstract Pregnancy is associated with increased levels of soluble (s) human leukocyte antigen (HLA)-G molecules, while during abortion these molecules are decreased. To date, little is known about the role of sHLA-G isoforms during abortion. In this study, we investigated the levels of total sHLA-G...

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Bibliographic Details
Published in:Human immunology 2016-04, Vol.77 (4), p.342-345
Main Authors: Zidi, Inès, Rizzo, Roberta, Bouaziz, Aicha, Laaribi, Ahmed Baligh, Zidi, Nour, Di Luca, Dario, Tlili, Henda, Bortolotti, Daria
Format: Article
Language:English
Subjects:
Abortion
Abortion, Habitual - blood
Abortion, Habitual - genetics
Abortion, Habitual - immunology
Adult
Alleles
Allergy and Immunology
Biomarkers
Case-Control Studies
Female
Gene Expression
HLA-G Antigens - blood
HLA-G Antigens - genetics
HLA-G Antigens - immunology
HLA-G5
Humans
Middle Aged
Pregnancy
RNA, Messenger - genetics
sHLA-G
sHLA-G1
Tunisia
Young Adult
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Summary:Abstract Pregnancy is associated with increased levels of soluble (s) human leukocyte antigen (HLA)-G molecules, while during abortion these molecules are decreased. To date, little is known about the role of sHLA-G isoforms during abortion. In this study, we investigated the levels of total sHLA-G and its isoforms: HLA-G1 (membrane shedded isoform) and alternative spliced HLA-G5 in plasma samples obtained from 55 women who had experienced spontaneous abortion, 108 pregnant healthy women and 56 non pregnant healthy women. We found that pregnant women exhibited higher amounts of sHLA-G compared to either non pregnant women or women with abortion. Among women who had experienced spontaneous abortion, women with recurrent abortions (RSA) had lower sHLA-G than women with only one abortion. In particular, RSA women were characterized by the absence of sHLA-G1 isoform, suggesting a possible implication in abortion event.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2016.01.019