Lymphocyte Subpopulations and Cytokine Levels in Experimental Hyperhomocysteinemia

Moderate exogenous hyperhomocysteinemia is associated with an increase in lymphocyte count (mainly at the expense of cytotoxic T cells), a 2-fold drop of the immunoregulatory index, and increase in TNF-α, IFN-γ, and IL-17α concentrations in the serum and in mononuclear cells. Homocysteine concentrat...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-07, Vol.159 (3), p.358-360
Main Authors: Fefelova, E. V., Tereshkov, P. P., Dutov, A. A., Tsybikov, N. N.
Format: Article
Language:English
Subjects:
Animals
B cells
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cysteine
Cystine
Cytokines
Cytokines - metabolism
Glutamate
Hyperhomocysteinemia - immunology
Hyperhomocysteinemia - metabolism
Interferon-gamma - metabolism
Interleukin-17 - metabolism
Internal Medicine
Laboratory Medicine
Lymphocyte Subsets - metabolism
Male
Pathology
Rats
T cells
Tumor Necrosis Factor-alpha - metabolism
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Summary:Moderate exogenous hyperhomocysteinemia is associated with an increase in lymphocyte count (mainly at the expense of cytotoxic T cells), a 2-fold drop of the immunoregulatory index, and increase in TNF-α, IFN-γ, and IL-17α concentrations in the serum and in mononuclear cells. Homocysteine concentration in the mononuclears remains unchanged.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2962-1