Molecular and clinical prognostic factors for favorable outcome following surgical resection of adult intramedullary spinal cord astrocytomas

Highlights • The majority of patients experienced improved neurological status after surgery. • No molecular characteristics were associated with postoperative outcomes. • Older age predicted decreased likelihood of achieving progression-free survival. • Preoperative motor symptoms and adjuvant chem...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2016-05, Vol.144, p.82-87
Main Authors: Roy, Xiao, Abdullah, Kalil G, Miller, Jacob A, Lubelski, Daniel, Steinmetz, Michael P, Shin, John H, Krishnaney, Ajit A, Mroz, Thomas E, Benzel, Edward C
Format: Article
Language:English
Subjects:
Adult
Age
Astrocytoma
Astrocytoma - diagnosis
Astrocytoma - surgery
Cervical Vertebrae - surgery
Chemotherapy
Clinical outcomes
Cohort Studies
Epidermal growth factor
Female
Follow-Up Studies
Gross total resection
Hospitals
Humans
Intramedullary
Male
Medical prognosis
Middle Aged
Modified McCormick scale
Multivariable regression
Neurology
Neurosurgery
Neurosurgical Procedures - trends
Patients
Plane of dissection
Prognosis
Progression-free survival
Radiation therapy
Retrospective Studies
Spinal Cord Neoplasms - diagnosis
Spinal Cord Neoplasms - surgery
Surgery
Thoracic Vertebrae - surgery
Treatment Outcome
Tumors
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Description
Summary:Highlights • The majority of patients experienced improved neurological status after surgery. • No molecular characteristics were associated with postoperative outcomes. • Older age predicted decreased likelihood of achieving progression-free survival. • Preoperative motor symptoms and adjuvant chemotherapy predicted poorer outcomes.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2016.03.009