Antitubercular Activity of Triterpenoids from Lippia turbinata

Assay-guided fractionation of the antitubercular MeOH-CH(2)Cl(2) extract obtained from Lippia turbinata led to the isolation of four novel triterpenoids-3beta,25-epoxy-3alpha,21alpha-dihydroxy-22beta-(3-methylbut-2-en-1-oyloxy)olean-12-ene-28-oic acid (1); 3beta,25-epoxy-3alpha,21alpha-dihydroxy-22b...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2001-01, Vol.64 (1), p.37-41
Main Authors: WäCHTER, Gerald A., VALCIC, Susanne, FRANZBLAU, Scott G., SUAREZ, Enrique, TIMMERMANN, Barbara N.
Format: Article
Language:English
Subjects:
Animals
Antitubercular Agents - chemistry
Antitubercular Agents - pharmacology
Antitubercular Agents - toxicity
Biological and medical sciences
Cercopithecus aethiops
Chile
General pharmacology
Lippia turbinata
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - toxicity
Plants, Toxic - chemistry
Triterpenes - chemistry
Triterpenes - pharmacology
Triterpenes - toxicity
triterpenoids
Vero Cells
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Summary:Assay-guided fractionation of the antitubercular MeOH-CH(2)Cl(2) extract obtained from Lippia turbinata led to the isolation of four novel triterpenoids-3beta,25-epoxy-3alpha,21alpha-dihydroxy-22beta-(3-methylbut-2-en-1-oyloxy)olean-12-ene-28-oic acid (1); 3beta,25-epoxy-3alpha,21alpha-dihydroxy-22beta-angeloyloxyolean-12-ene-28-oic acid (2); 3beta,25-epoxy-3alpha,21alpha-dihydroxy-22beta-tigloyloxyolean-12-ene-28-oic acid (3); and 3beta,25-epoxy-3alpha-hydroxy-22beta-(2-methylbutan-1-oyloxy)olean-12-ene-28-oic acid (4)-together with the known triterpenoids lantanilic acid (5), camaric acid (6), lantanolic acid (7), and rehmannic acid (8). The MIC values of 1-8 for growth inhibition of Mycobacterium tuberculosis were determined in the radiorespirometric BACTEC system.
ISSN:0163-3864
1520-6025
DOI:10.1021/np000267b