Flavonol Glycosides and Steroidal Saponins from the Leaves of Cestrum nocturnum and Their Cytotoxicity

Phytochemical analysis of the leaves of Cestrum nocturnum (Solanaceae) resulted in the isolation of two new flavonol glycosides (1, 2) and seven steroidal saponins (3-9), including four new ones (4, 6, 7, and 9). The structures of the new compounds were determined by spectroscopic analysis, includin...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2001-01, Vol.64 (1), p.17-22
Main Authors: MIMAKI, Yoshihiro, WATANABE, Kazuki, ANDO, Yuka, SAKUMA, Chiseko, SASHIDA, Yutaka, FURUYA, Shigenori, SAKAGAMI, Hiroshi
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Cestrum nocturnum
Fibroblasts
Flavonoids - chemistry
Flavonoids - isolation & purification
Flavonoids - pharmacology
flavonol glycosides
General pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
HSC-2 cells
Humans
Hydrolysis
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Conformation
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Leaves - chemistry
Saponins - chemistry
Saponins - isolation & purification
Saponins - pharmacology
Skin Neoplasms - drug therapy
Solanaceae - chemistry
Spectrometry, Mass, Fast Atom Bombardment
steroidal saponins
Tumor Cells, Cultured
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Summary:Phytochemical analysis of the leaves of Cestrum nocturnum (Solanaceae) resulted in the isolation of two new flavonol glycosides (1, 2) and seven steroidal saponins (3-9), including four new ones (4, 6, 7, and 9). The structures of the new compounds were determined by spectroscopic analysis, including 2D NMR data, and the results of hydrolytic cleavage. Cytotoxic activities of the isolated compounds against human oral squamous cell carcinoma-(HSC-2) cells and normal human gingival fibroblasts are reported.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0003701