Cytogenetic analysis of children under long-term antibacterial therapy with nitroheterocyclic compound furagin

Cytogenetic analysis of chromosome aberrations (CAs) and sister chromatid exchanges (SCEs) was performed in 109 blood samples from 95 pediatric patients with urinary tract infections (UTIs). Children were exposed to diagnostic levels of X-rays during voiding cystourethrography and subsequently treat...

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Bibliographic Details
Published in:Mutation research. Genetic toxicology and environmental mutagenesis 2001-04, Vol.491 (1), p.25-30
Main Authors: Slapšyt≐, G., Jankauskien≐, A., Mierauskien≐, J., Lazutka, J.R.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biological effects of radiation
Chromosome aberration
Fundamental and applied biological sciences. Psychology
Furagin
Human lymphocytes
Ionizing radiation
Ionizing radiations
Medical sciences
nitrofurantoin
Pharmacology. Drug treatments
Sister chromatid exchange
Tissues, organs and organisms biophysics
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Summary:Cytogenetic analysis of chromosome aberrations (CAs) and sister chromatid exchanges (SCEs) was performed in 109 blood samples from 95 pediatric patients with urinary tract infections (UTIs). Children were exposed to diagnostic levels of X-rays during voiding cystourethrography and subsequently treated for one to 12 months with low doses of furagin — N-(5-nitro-2-furyl)-allylidene-1-aminohydantoin. Furagin is 2-substituted 5-nitrofuran, chemically and structurally similar to well-known antibacterial compound nitrofurantoin. Increased frequencies of CAs were found in children undergoing voiding cystourethrography as compared with the unexposed, acentric fragments being the most frequent alteration (2.03 versus 0.88 per 100 cells, P=0.006). However, a significant decrease in the frequency of acentric fragments was determined with the time elapsed since X-ray examination was performed. A time-independent increase in SCE frequency was found in lymphocytes of children treated with furagin. Total CA frequency did not differ significantly between groups of children with various duration of furagin treatment. However, frequency of chromatid exchanges (triradials and quadriradials) increased significantly with duration of treatment.
ISSN:1383-5718
1879-3592
DOI:10.1016/S1383-5718(01)00131-0